Genetic panels for hereditary cancers Predict&Prevent - 138 genes

What is the Predict&Prevent test?

Predict&Prevent is a genetic test that detects changes in genes associated with an increased risk of hereditary cancers. It analyzes 138 genes linked to more than 30 types of cancer, including breast, ovarian, colorectal, prostate, skin, kidney, and pancreatic cancer. You can find the full list of diseases and tested genes in the documents section.

The full list of tested genes and diseases, as well as more detailed information, can be found on the Centrum Medyczne Damiana website (Comprehensive Cancer Predisposition Panel) or HERE Predict_Prevent_List_of_Genes_and_Diseases_How_to_Interpret_the_Result.pdf 

You can choose:  

✅ A comprehensive panel that analyzes all 138 genes.  

✅ One of 13 panels focused on specific cancers.  
 
The test price includes a free consultation with a geneticist after receiving the results. 

Who is the Predict&Prevent test for? 

This test is intended for adults who want to check their genetic risk for hereditary cancers and proactively manage their health. It is particularly recommended for:

• Individuals with a family history of early-onset cancer – when relatives were diagnosed before the age of 50.
• Individuals with multiple cases of cancer in the family – three or more close relatives diagnosed with cancer.
• Patients with a diagnosed cancer – who want to determine whether there is a genetic cause of their disease.
• Individuals with a genetically burdened family – when a family member has been found to carry a genetic variant associated with cancer development.
• Individuals with characteristic symptoms – e.g., multiple colon polyps, indicating a hereditary nature of the disease. 

Before deciding on the test, it is advisable to consult a geneticist. 

How can the Predict&Prevent test help you? 

1. Understanding individual risk – the test identifies hereditary genetic variants that increase cancer risk, allowing for early preventive measures.
2. Personalized prevention plan – based on test results, an individual strategy can be developed, including regular screenings and lifestyle changes.
3. Support in treatment – knowing the test results helps select targeted treatment methods if cancer has already been diagnosed.
4. Protecting the family – identifying potential genetic carriers in the family allows for early preventive measures for relatives.
5. Early detection – increasing the chances of detecting cancer at an early stage, improving treatment effectiveness and prognosis.  

How to prepare for the test? 

• The test does not require special preparation. You do not need to fast or stop taking medications. A doctor's referral is not required. 
• After purchasing the test, visit the blood collection point during business hours at your chosen facility. 
• You can complete the test within 3 months of purchase (from the date specified in the order confirmation). 

How does the Predict&Prevent test work? 

• Purchase Predict&Prevent – select the appropriate panel and complete the purchase at Centrum Medicover facility, Medicover Hospital or online. 
• Come for blood collection during the operating hours of our facilities.  
• The test does not require special preparation. You do not need to fast or stop taking medications. A doctor's referral is not required. 
• The collected sample is sent for analysis at Medicover Genetics' modern laboratories in Germany. 
• Results will be available within 3-4 weeks from the time the sample reaches the laboratory. The test result will be sent to the provided email address. 
• FREE GENETIC CONSULTATION – after receiving the test report, you can discuss your results with a geneticist within 3 months. 

How long does it take to get the result and how to interpret it? 

The test report (in Polish) will be sent to the provided email address within 30 days after the sample reaches the laboratory. 

It is important to note that the interpretation of genetic results depends on the patient’s complete clinical picture. 

After the test, a comprehensive report will be prepared, containing a detailed interpretation of the detected genetic changes. The report will include next-generation sequencing (NGS) analysis of the selected genetic panel or the comprehensive panel of all genes. 

Reported variant types

A report of the conducted test (in Polish) will be sent to the previously provided email address within 3 to 4 weeks of the sample being delivered to the laboratory. 
Please note that the interpretation of genetic results depends on the exact clinical picture of the patient. 
After the test is completed, a comprehensive report will be prepared, which includes a detailed interpretation of the detected genetic changes. The report result will include the analysis of the next generation sequencing (NGS) of the selected genetic panel or a comprehensive panel of all genes.

• “Pathogenic / Likely Pathogenic Variant Detected” – indicates an increased risk of cancer but does not mean that the disease will necessarily develop. A consultation with a doctor and preventive actions are recommended. If you already have cancer, the result may help in selecting the appropriate treatment and provide valuable information for your family.
• “Variant of Uncertain Clinical Significance (VUS)” – currently, there is no evidence linking it to cancer development, but further monitoring and possible re-evaluation in the future are recommended. 
• “No Clinically Significant Variant Detected” – no changes increasing cancer risk were found. However, this does not entirely eliminate the risk, so regular health monitoring and a healthy lifestyle remain important. 

For accurate result interpretation and next steps, a consultation with a clinical geneticist is recommended. A free consultation is provided upon receiving the results. 

The result of the test allows you to estimate your risk of developing cancer from genetic causes. With this knowledge, you can consciously take care of your health and take relevant measures, such as making lifestyle changes and, together with your doctor, adjusting the type and frequency of check-ups. What's more, if you do get sick, knowledge of your genetic status can help you choose the best method and start treatment quickly.

Worth knowing:

• Cancer is one of the leading causes of death worldwide.
• About 10% of cancers are hereditary. The risk of passing on and inheriting a harmful genetic variant is as high as 50%.
• Up to 40% of cancer-related deaths can be avoided with lifestyle changes.

Why choose Predict&Prevent?  

The Predict&Prevent test offers a wide selection of genetic panels that help confirm diagnoses, ensure accurate recognition, support treatment decisions, provide patient care, and conduct screenings for family members at increased risk.  

 The test is performed by Medicover Genetics in Germany – a laboratory with years of experience.  

Technical details about the NGS test:  

• Whole exons and selected intronic regions are analyzed.  
• Detected mutations: SNV (single nucleotide variants), small insertions/deletions (INDEL), and copy number variations (CNV).  
• Reference human genome: GRCh38.  
• Average read depth: 100x.  
• Coverage: >97–99% at a depth of at least 20x.  
• Variant classification follows ACMG guidelines.  

Where can you take the Predict&Prevent test?  

The Predict&Prevent test is available at Medicover Hospital or Medical Center.